Beta-Elemonic acid
elemonic acid
CAS: 28282-25-9
Molecular Formula: C30H46O3
Beta-Elemonic acid - Names and Identifiers
Beta-Elemonic acid - Physico-chemical Properties
| Molecular Formula | C30H46O3 |
| Molar Mass | 454.68 |
| Density | 1.07 |
| Melting Point | 224-225°C |
| Boling Point | 565.2±50.0 °C(Predicted) |
| Specific Rotation(α) | (CHCl3)+31 |
| Solubility | Soluble in chloroform and methanol |
| Appearance | White crystal |
| pKa | 4.65±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD00467083 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from frankincense. |
| In vitro study | β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC 50 value following a 24-h exposure to β-elemonic acid was 6.92 µM. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells. |
Beta-Elemonic acid - Reference Information
| biological activity | β-Elemonic acid is a triterpene isolated from frankinthus trees. β-Elemonic acid induces apoptosis, reactive oxygen species (ROS) and COX-2 expression, and inhibits prolyl endopeptidase. β-Elemonic acid has anti-cancer and anti-inflammatory effects. |
| target | COX-2 |
| in vitro study | beta-elemonic acid (1, 3, 10, 20 µm; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner.β-elemonic acid (1, 3, 10, 20 m; 24 hours) exercise potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner.The IC 50 value following a 24-h exposure to beta-elemonic acid was 6.92 m. beta-elemonic acid (20 m; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase. beta-elemonic acid (1, 3, 10, 20 m; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from frankincense. |
Last Update：2024-04-09 21:31:58
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View History
Beta-Elemonic acid
AKOS B025766
2-AMINO-4-(4-CYCLOHEXYL-PHENYL)-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
Cyclohexanecarboxylic acid, 2-[3-oxo-3-[(phenylmethyl)amino]propyl]hydrazide
AKOS LT-1127X407
短裸甲藻毒素3
1-(4-羟基苯基)-2-(甲基氨基)乙醇
Amitraz Metabolite Hydrochloride
3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]propanohydrazide
DesMethyl IopaMidol
AKOS B025766
2-AMINO-4-(4-CYCLOHEXYL-PHENYL)-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER
Cyclohexanecarboxylic acid, 2-[3-oxo-3-[(phenylmethyl)amino]propyl]hydrazide
AKOS LT-1127X407
短裸甲藻毒素3
1-(4-羟基苯基)-2-(甲基氨基)乙醇
Amitraz Metabolite Hydrochloride
3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]propanohydrazide
DesMethyl IopaMidol